World Journal of Traditional Chinese Medicine

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 8  |  Issue : 4  |  Page : 530--538

The mechanism of Panax Notoginseng in the treatment of heart failure based on biological analysis


Lei Peng1, Lin Ma2, Qian-Qian Jiang3, Xue Tian3, Ming-Yan Shao3, Chang-Xiang Li3, Xiao-Qian Sun3, Xiao Ma4, Xu Chen2, Chun Li2 
1 Xincun Community Health Service Center, Beijing, China
2 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China
3 School of Life Science, Beijing University of Chinese Medicine, Beijing, China
4 Department of Cardiovascular Medicine, Cardiorenal Research Laboratory, Mayo Clinic, Rochester, MN, USA

Correspondence Address:
Prof. Chun Li
School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029
China
Dr. Xu Chen
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029
China

Objective: This study aimed to explore the mechanism of Panax notoginseng (PNS) in the treatment of heart failure (HF) based on network pharmacology analysis combined with experimental verification. Materials and Methods: The potential targets and key pathways of effective components of PNS in the treatment of HF were revealed using network pharmacology. The postacute myocardial infarction (MI) HF rat model was established by ligating the left anterior descending branch of the coronary artery. The rats were divided into three groups: model, PNS, and fenofibrate groups. PNS (0.75 g/kg) and fenofibrate (10 mg/kg) were administered for 28 days. The efficacy and target mechanism of PNS in the treatment of HF were verified by cardiac ultrasound, Masson staining, and western blotting (WB) techniques. Results: The results of network pharmacology showed that seven potentially active compounds, such as quercetin, were obtained, involving 105 targets of HF; GO function was enriched to 1240 items; and KEGG enrichment covered 1240 signal pathways. The results of echocardiography showed that EF and FS of HF rats after MI were significantly increased, while Left ventricular internal dimension diastole (LVIDd) and Left ventricular internal dimension systole (LVIDs) were significantly decreased (P < 0.001, P < 0.05). Masson staining showed that PNS could reduce the degree of myocardial fibrosis (MF) in HF. The results of WB showed that PNS could reduce the expression of the p-p38-MAPK, transforming growth factor-beta (TGF-β), and Smad3 in HF rats. Conclusion: PNS inhibited MF and treated HF by regulating p-p38 MAPK-TGF-β pathway, which lays a theoretical foundation for further study of its pharmacological mechanism and key target.


How to cite this article:
Peng L, Ma L, Jiang QQ, Tian X, Shao MY, Li CX, Sun XQ, Ma X, Chen X, Li C. The mechanism of Panax Notoginseng in the treatment of heart failure based on biological analysis.World J Tradit Chin Med 2022;8:530-538


How to cite this URL:
Peng L, Ma L, Jiang QQ, Tian X, Shao MY, Li CX, Sun XQ, Ma X, Chen X, Li C. The mechanism of Panax Notoginseng in the treatment of heart failure based on biological analysis. World J Tradit Chin Med [serial online] 2022 [cited 2023 Feb 3 ];8:530-538
Available from: https://www.wjtcm.net/article.asp?issn=2311-8571;year=2022;volume=8;issue=4;spage=530;epage=538;aulast=Peng;type=0