World Journal of Traditional Chinese Medicine

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 7  |  Issue : 3  |  Page : 332--338

Panax notoginseng saponins increases the blood concentration of nifedipine by inhibiting CYP3A4 enzyme through PXR- and CAR-Mediated pathway


Qiu-Hong Li1, Jiao Zhao1, Ai-Xia Ju1, Yong Hu1, Qing-Song Qie1, Hong-Bin Xiao1, Guang Xu2, Xi-Jun Wang1 
1 Clinical Pharmacy Laboratory, Department of Pharmaceutics, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China
2 9601 Medical Center Drive, Rockville, MD, USA

Correspondence Address:
Prof. Xi-Jun Wang
National Chinmedomics Research Center, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040
China




How to cite this article:
Li QH, Zhao J, Ju AX, Hu Y, Qie QS, Xiao HB, Xu G, Wang XJ. Panax notoginseng saponins increases the blood concentration of nifedipine by inhibiting CYP3A4 enzyme through PXR- and CAR-Mediated pathway.World J Tradit Chin Med 2021;7:332-338


How to cite this URL:
Li QH, Zhao J, Ju AX, Hu Y, Qie QS, Xiao HB, Xu G, Wang XJ. Panax notoginseng saponins increases the blood concentration of nifedipine by inhibiting CYP3A4 enzyme through PXR- and CAR-Mediated pathway. World J Tradit Chin Med [serial online] 2021 [cited 2022 Aug 8 ];7:332-338
Available from: https://www.wjtcm.net/article.asp?issn=2311-8571;year=2021;volume=7;issue=3;spage=332;epage=338;aulast=Li;type=0