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Research progress on the pharmacological mechanisms of Chinese Medicines that Tonify Qi and activate blood against cerebral ischemia/reperfusion injury


1 Beijing University of Chinese Medicine, Graduate School, Beijing 100029; Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia, Beijing 100091, China
2 Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia, Beijing 100091, China
3 NICM Health Research Institute, Western Sydney University, Westmead, NSW 2751, Australia
4 Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia, Beijing 100091, China; NICM Health Research Institute, Western Sydney University, Westmead, NSW 2751, Australia

Correspondence Address:
Jian-Xun Liu,
Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia, Beijing 100091; NICM Health Research Institute, Western Sydney University, Westmead, NSW 2751

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/wjtcm.wjtcm_21_21

Cerebral ischemia-reperfusion injury (CIRI) refers to a pathological phenomenon that aggravates the injury after the restoration of blood perfusion and oxygen supply to the cerebral ischemia-induced tissues and organs, with a relatively high incidence. The traditional Chinese medicine (TCM) believes that Qi deficiency and blood stasis are the cause of CIRI. Therefore, Chinese medicine for tonifying Qi and activating blood is regarded as an important choice for the treatment of CIRI. In recent years, it has been found that many Chinese herbal medical ingredients and compound Chinese medicine (CCM) have significant anti-CIRI effects, and their mechanisms of action mainly include improving brain blood supply, neuroprotection, regulating signal pathways such as TLR4/HO-1/Bcl-2, protecting mitochondrial function, regulating related protein levels, and regulating oxidative molecule levels. This article summarizes and introduces the pharmacological mechanisms of Tonifying-Qi and activating-blood Chinese medicine and CCM which have the function of anti-CIRI. Our goal is to provide effective reference for further researches on the cerebral protection of related TCMs or compounds and their clinical application.


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