Predicting the 7th day efficacy of acupoint application of Chinese herbs (Xiao Zhong Zhi Tong Tie) in patients with diarrhea – A machine-learning model based on XGBoost algorithm

Song Sheng; Rui Li; Xing Wang; Hong-Yang Gao; Yan-Hong Zhang; Feng-Qin Xu

doi:10.4103/wjtcm.WJTCM_60_21

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ORIGINAL ARTICLE

Year : 2022 \| Volume : 8 \| Issue : 2 \| Page : 257-261

Predicting the 7^th day efficacy of acupoint application of Chinese herbs (Xiao Zhong Zhi Tong Tie) in patients with diarrhea – A machine-learning model based on XGBoost algorithm Song Sheng¹, Rui Li², Xing Wang¹, Hong-Yang Gao¹, Yan-Hong Zhang¹, Feng-Qin Xu³ ¹ Department of Emergency, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China ² Institute of Clinical Pharmacology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China ³ Institute of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China Correspondence Address: Feng-Qin Xu Institute of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing China Source of Support: None, Conflict of Interest: None DOI: 10.4103/wjtcm.WJTCM_60_21

Objective: Extreme gradient boosting (XGBoost) was used to predict the 7^th day efficacy of the acupoint application (AP) of Chinese herbs (Xiao Zhong Zhi Tong Tie) in patients with diarrhea. Materials and Methods: We consecutively collected medical records of patients with diarrhea nationwide on the Chun Bo Wan Xiang cloud platform from August 22 to November 5, 2020. Demographic and clinical data and the fecal properties were included in this study. We established the XGBoost model to predict the 7^th day efficacy of AP in patients with diarrhea. The XGBoost model was evaluated using the area under the receiver operating characteristic (ROC) curve (AUC). We next compared the performance of XGBoost with that of artificial neural network (ANN), ANN + boosting, ANN + bagging, and support vector machine (SVM). Results: The XGBoost model provided a prediction accuracy of 84.86% (95% confidence interval = 82.74% to 86.81%) and the ROC curve analysis showed an AUC of 0.81. The top-three variables with the highest importance are age, duration of diarrhea, and region (North). Our study revealed that XGBoost was not superior to ANN, ANN + boosting, ANN + bagging, and SVM. Conclusions: The established XGBoost model for predicting the 7^th day efficacy of AP in patients with diarrhea exhibited good accuracy and precision, which can be used for efficacy prediction.



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