| REVIEW ARTICLE |
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| Year : 2022 | Volume
: 8
| Issue : 1 | Page : 59-76 |
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Engineered production of bioactive natural products from medicinal plants
Ozkan Fidan1, Jie Ren2, Jixun Zhan2
1 Department of Bioengineering, Faculty of Life and Natural Sciences, Abdullah Gül University, Kayseri, Turkey
2 Department of Biological Engineering, College of Engineering, Utah State University, Logan, Utah, USA
Correspondence Address:
Dr. Jixun Zhan
Department of Biological Engineering, College of Engineering, Utah State University, Logan, Utah 84322-4105
USA
Dr. Ozkan Fidan
Department of Bioengineering, Faculty of Life and Natural Sciences, Abdullah Gul University, Kayseri 38080
Turkey
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/wjtcm.wjtcm_66_21
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Plant natural products have been particularly important due to their use in food, cosmetic, and pharmaceutical industries. In particular, Traditional Chinese Medicine provides a precious potential for the discovery of bioactive natural products and development of novel modern medicines. However, the existing production methods for plant natural products such as chemical synthesis and plant extraction does not meet the current demand. Due to their environmental and economic concerns, engineered production of valuable natural products in microbial hosts has become an attractive alternative platform. This review covers the recent advances in the engineered production of plant natural products in microorganisms. A special focus was placed on the biotechnological production of plant-derived terpenoids, flavonoids, and alkaloids. Some successful examples of engineered production of plant natural products (or their precursors) such as artemisinin, paclitaxel, naringenin, quercetin, berberine, and noscapine are summarized. This clearly indicates that the engineered production method is a promising approach with various advantages over current methods.
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