A review of the pharmacology, application, ethnopharmacology, phytochemistry, quality control, processing, toxicology, and pharmacokinetics of Paridis Rhizoma

Song-Tao Liu; Huan Yu; A-Jiao Hou; Wen-Jing Man; Jia-Xu Zhang; Song Wang; Xue-Jiao Wang; Sen-Wang Zheng; Xiao-Lin Su; Liu Yang

doi:10.4103/wjtcm.wjtcm_4_21

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REVIEW ARTICLE

Year : 2022 | Volume : 8 | Issue : 1 | Page : 21-49

A review of the pharmacology, application, ethnopharmacology, phytochemistry, quality control, processing, toxicology, and pharmacokinetics of Paridis Rhizoma

Song-Tao Liu¹, Huan Yu¹, A-Jiao Hou¹, Wen-Jing Man¹, Jia-Xu Zhang¹, Song Wang¹, Xue-Jiao Wang¹, Sen-Wang Zheng¹, Xiao-Lin Su², Liu Yang¹
¹ Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Harbin, China
² Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States

Correspondence Address:
Liu Yang
Heilongjiang University of Chinese Medicine, Harbin, 150040
China

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/wjtcm.wjtcm_4_21

Paridis Rhizoma (PR) is also known as the flower with seven leaves and one branch, PR with golden thread, etc. It tastes bitter, numb, and slightly cold and has little poison. It is often used for the treatment of external skin infection, sore throat, snake bite, fall pain, frightening convulsion, and other diseases. PR has analgesic, sedative, anti-inflammatory, hemostatic, antitumor, antibacterial, antiviral, and renal and liver protective effects; inhibition of angiogenesis; immune regulation; and antioxidant and cardiovascular effects, and antifertility and anti-early pregnancy sperm killing effects. Steroidal saponins, β-ecdysone, polysaccharides, microelements, flavonoid glycosides, and amino acids were isolated from PR. In this paper, its pharmacology, application, ethnopharmacology, phytochemistry, quality control, toxicology, and pharmacokinetics were reviewed. This information suggests that we should focus on the development of new drugs related to PR, including specific ingredients, so as to make PR play a greater therapeutic potential. At the same time, attention should be paid to the rational use of PR resources to avoid excessive using, resulting in resource shortage. Therefore, we can carry out the research on the substitutes of PR, a large-scale planting of (Paridis Rhizoma) PR, and develop the same genus of PR and other resources. So far, great progress has been made in pharmacology and phytochemistry, especially in antitumor research, and many traditional uses have been confirmed and clarified by modern pharmacological research. However, there are few studies on the mechanism of its pharmacological action and few studies on processing. To develop new drugs in the future, more studies and experiments are still needed to prove the effect of PR and explore more new effects.

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