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Year : 2015  |  Volume : 1  |  Issue : 2  |  Page : 24-37

Development of high performance liquid chromatography and mass spectrometry: a Key engine of TCM modernization

1 Agilent Technologies (China) Co., Ltd., No. 3, Wang Jing Bei Lu, Chao Yang District, Beijing 100102, P.R. China
2 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Correspondence Address:
Tao Bo
Agilent Technologies (China) Co., Ltd., Wang Jing Bei Lu, Chao Yang District, Beijing 100102
P.R. China
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Source of Support: None, Conflict of Interest: None

DOI: 10.15806/j.issn.2311-8571.2015.0006

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Traditional Chinese Medicine (TCM) has been popular for thousand years in prevention and treatment of chronic diseases synergistically with Western medicine while producing mild healing effects and lower side effects. Although many TCMs have been proven effective by modern pharmacological studies and clinical trials, their bioactive constituents and the remedial mechanisms are still not well understood. Researchers have made great efforts to explore the real theory of TCM for many years with different strategies. Development of high performance liquid chromatography (HPLC) and mass spectrometry within recent decade can provide scientists with robust technologies for disclosing the mysterious mask of TCM. In this paper, important innovations of HPLC and mass spectrometry are reviewed in the application of TCM analysis from single compound identification to metabolomic strategy. Abbreviations: TCM, Traditional Chinese Medicine; Q-TOF, Quadrupole time-of-flight mass spectrometry; LC, Liquid chromatography; CE, Capillary electrophoresis; SFC, supercritical-fluid chromatography; QQQ, triple quadrapole

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